The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.
Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, DETOX PWD which results from the chromosomal translocation t(10;11)(p13;q14).CALM is sufficient to drive clathrin assembly in vitro on lipid monolaye