THE CLATHRIN ASSEMBLY PROTEIN PICALM IS REQUIRED FOR ERYTHROID MATURATION AND TRANSFERRIN INTERNALIZATION IN MICE.

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.

Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, DETOX PWD which results from the chromosomal translocation t(10;11)(p13;q14).CALM is sufficient to drive clathrin assembly in vitro on lipid monolaye

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Multi-photon resonances in Josephson junction-cavity circuits

We explore the dissipative dynamics of nonlinearly driven oscillator systems tuned to resonances where multiple excitations are generated.Such systems are readily realised in circuit QED systems combining Josephson junctions with a microwave cavity and a drive achieved either through flux or voltage bias.For resonances involving three or more photo

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PRACTICAL-ORIENTED EDUCATION IN THE INTERNSHIP IS THE BASIS OF THE FORMATION AND DEVELOPMENT OF THE PROFESSIONAL COMPETENCE OF THE FUTURE DOCTOR

The professional orientation of modern education, especially at the higher medical school, should have a personality-oriented approach.The concept of the practical orientation of learning, as the main component of modern didactic principles, is to provide clear links and interdependencies between the process of obtaining professional knowledge and

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